Welcome to Bio354 Pathophysiology

Course Format

We will meet MWF from 10:00 - 10:50 AM in Hudson 209. Please refer to the course calendar for weekly topics.

Course Grading

This course will be taught on a case study approach. Weekly case study assignments and case-study based quizzes will constitute the course grade

Readings

Textbook: Hammer, Gary and Stephen McPhee. Pathophysiology of Disease: An Introduction to Clinical Medicine 8E. McGraw-Hill Publishers, 2018.

Book chapters are assigned as according to the class calendar. Please read each chapter before Monday's class. Additional reading assignments will be posted for each week, to be discussed in class.

Tentative outline of topics

I.        Definition and etiology of disease

A.     Genetic

B.      Immune

C.      Infectious

II.      Cellular basis of dysfunction

A.     Membrane dysfunction

1.       Transport

2.       Membrane potential

B.      Receptors/signaling

C.      Cell cycle dysfunction

D.     Enzyme/metabolic dysfunction

E.      Structural deficiencies

F.      Secretory dysfunction

III.   Selected disorders of major body systems

A.     Cardiovascular

1.       Hypertension

2.       Myocardial infarction

3.       Stroke

4.       Arrhythmia

5.       Peripheral blood vessel disease

6.       Blood disorders

B.      Endocrine

1.       Pancreas: Diabetes mellitus

2.       Thyroid: Graves’ disease, Hashimoto’s disease

3.       Hypothalamus: diabetes insipidus

4.       Pituitary: Dwarfism, gigantism

5.       Parathyroid: hypo/hypercalcemia

6.       Adrenal: Cushing’s, Addison’s

C.      Neurological

1.       Alzheimer’s

2.       Cerebral palsy

3.       Epilepsy

4.       Multiple sclerosis

5.       Parkinson’s

D.     Metabolic

1.       Diabetes

2.       Phenylketonuria

3.       Maple syrup urine disease

E.      Musculoskeletal

1.       Muscular dystrophy

2.       Osteoporosis

3.       Lou Gehrig’s Disease

4.       Myasthenia gravis

5.       Polymyositis

F.      Digestive

1.       Gastroesophageal reflux disease

2.       Irritable bowel/Crohn’s

3.       Gallstones

4.       Diverticulosis

5.       Hepatitis

6.       Exocrine pancreas insufficiency

7.       Diarrhea

G.     Urogenital

1.       Chronic kidney disease

2.       Kidney stones

3.       Glomerulonephritis

H.     Immune

1.       Immune deficiency

2.       Allergy

3.       Auto-immune disease

I.        Respiratory

1.       Asthma

2.       Chronic obstructive pulmonary disease

3.       Emphysema

4.       Cystic fibrosis

J.        Integumentary

1.       Acne

2.       Alopecia

3.       Atopic dermatitis

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