Bio 406 - Medical Microbiology
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Additional Reading

1. Marshall, B.M., D.J. Ochieng and S.B. Levy. Commensals: Underappreciated reservoir of antibiotic resistance. Microbe 4(5):231-238, 2009.
2. Dobson A, P. Cotter, C. Hill and R.P.Ross. Bacteriocin Production: A Probiotic Trait? AEM 78(1):1-6, 2012.
3. Casadevall, A. Cards of Virulence and the Global Virulome for Humans. Microbe 1(8):359-364, 2006.
4. Blanke, S.R. Portals and Pathways: Principles of Bacterial Toxin Entry into Host Cells. Microbe 1(1):26-32, 2006.
5. Diaz, M.R. Bead suspension arrays for identifying fungal pathogens. Microbe 2(2):74 - 81, 2007.
6. Wegerhoff, F. It's a bug's life - Specimen collection, transport, and viability. Microbe 1(4):180 - 184, 2006.
7. Analysis with Mathematical Models Provides Insights into Infectious Diseases Microbe 4 (4):176-182, 2009 
8. Woolhouse, M.E.J. Where Do Emerging Pathogens Come from? Microbe 1(11):511-515, 2006.
9. Calisher, C.H., K. V. Holmes, S. R. Dominguez, T. Schountz, and P. Cryan. Bats Prove To Be Rich Reservoirs for Emerging Viruses. Microbe 3(11):521-528, 2008.

10. Kim, K.S. How pathogens penetrate the blood-brain barrier. Microbe 9(12):487-492, 2014.

11. Weiman, S. Immune system variations affect responses to pathogens. Microbe 9(7):278-281, 2014.

12. Cherry, J.D. Historical Perspective on Pertussis and use of vaccines to prevent it. Microbe 2(3):139 - 145, 2007.

13. Weiman, S. Bugs as Drugs: Bacteria as therapeutics against diseases. Microbe 9(11):437-441, 2014.
14. Sahl, H.-G. and G. Bierbaum. Multiple activities in natural antimicrobials. Microbe 3(10):467 - 473, 2008.
15. Baltz, R.H. Antimicrobials from Actinomycetes: Back to the future. Microbe 2(3):125 - 131, 2007.
16. Poole, K. Bacterial multidrug efflux pumps serve other functions. Microbe 3(4):179 - 185, 2008.
17. Hurd, H. S. Assessing Risks to Human Health from Antibiotic Use in Food Animals. Microbe 1(3):115-119, 2006.
18. Reyes-Robles, T., A. Alonzo and V.J. Torres. S. aureus virulence factors thwart host immune responses. Microbe 9(6):240-244, 2014.
19. S. K. Jain, G. Lamichhane, S. Nimmagadda, M. G. Pomper, and W. R. Bishai. Antibiotic Treatment of Tuberculosis: Old Problems, New Solutions. Microbe 3(6):285 - 292, 2008.
20. Quale, J. Global Spread of Carbapenemase-Producing Klebsiella pneumoniae. Microbe 3(11):516-520, 2008.
21. Osorio, G. & A. Camilli. Hidden Dimensions of Vibrio cholerae pathogenesis. ASM News 69(8):396-401, 2003.
22. Webster, R.G., Malik Peiris, J.S., Webby, R.S. and Guan, Y. H7N9 Influenza: What we learned from H5N1. Microbe 8(12):499 - 505, 2013.
23. Cevik, Kupalli, Kindrachuk and Peiris. Virology, transmission and pathogenesis of SARS-CoV-2. BMJ 2020;371:m3862
24. Priola, S.A. How animal prions cause disease in humans. Microbe 3(12):568-575, 2008.

25. Mylonakis, E. Who killed the worm and other fungal pathogenesis insights. Microbe 2(12):600-606, 2007.

26. Gauthier, G. and B.S. Klein. Insights into Fungal Morphogenesis and Immune Evasion. Microbe 3(9):416-423, 2008.

27. Radke, J.R., C.A. Eibs and P.D. Fox. Host cell-directed interactions with Toxoplasma influence pathogenesis. Microbe 2(5):244 - 250, 2007.

28. Weiman, S. Pathogens, parasites exploit exosomes as delivery vehicles. Microbe 8(8):315 - 320, 2013.

Contagion (Robin Cook)

This book can be purchased inexpensively through Amazon.com, eBay, or Barnes & Noble. I would ask that everyone will have read the book prior to the first exam. Although fictional, this book illustrates several interesting infectious disease cases and is hopefully an enjoyable read.

Questions 

1. What is a nosocomial infection? Why was Mr. Nodelman's infection first thought to be nosocomial?
2. Explain what signs led Jack to propose plague as the possible cause of Mr. Nodelman's death?
3. What other infectious agents were proposed as a possibility for his disease? What pathological observation led to these agents?
4. Of what diseases did the other patients in this book die?
5. For each of the diseases (Mr. Nodelman, Susanne Hard, Donald Lagenthorpe, Carlo Pacini, Kevin Carpenter) what is/are the:
   • Pathogen
   • Symptoms
   • Clinical/pathological findings
   • Method of diagnosis/identification
   • Mode of transmission
6. What is epidemiology? What is an index case?

Other infectious disease readings

• Vector (Robin Cook) - anthrax, botulism (fiction)
• The Hot Zone (Richard Preston) - Ebola (non-fiction)

On-line articles and selected readings

• Emerging infectious diseases: http://www.cdc.gov/ncidod/EID/index.htm
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