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Leprosy (Hansen's Disease) is a slow degenerative disease brought on by the patient's immune response to Mycobacterium leprae. In patients with a healthy cell-mediate immune response, there are few bacilli present (= paucibacillary) and tuberculoid skin lesions are present. In the lepromatous form, many bacteria are observed (multibacillary) due to a defective cell-mediated immunity. Nerve damage and tissue destruction result.