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Aspergillosis Aspergillosis is an opportunistic fungal infection by Aspergillus flavus, A. fumigatus and other Aspergillus species. In immunocompromised individuals such as AIDS this mold can establish a respiratory infection and spread invasively into adjacent tissues. The main problems associated with Aspergillus are hypersensitivities and food intoxication (aflatoxin), but invasive disease in immunocompromised patients represents the greatest mortality.