Cytomegalovirus Disease
Cytomegalovirus
inclusion disease is an infection by cytomegalovirus (CMV). The hallmark of
these infections are cells that enlarge and have a basophilic nuclear inclusion
body. CMV infections cause no symptoms or mono-like symptoms in adults and
serious congenital infections in newborns.
Summary
- Cause: Cytomegalovirus
- Transmission: body fluids (STD), organ transplants
- Symptoms: Asymptomatic to mono-like in most; rash in newborns
- Pathogenesis: CMV infects many cell types, including monocytes and
duct epithelial cells, causing cells to swell.
- Complications: birth defects, encephalitis, or death in fetus;
widespread infections in immunocompromised (AIDS)
- Treatment: Ganciclovir